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Can benadryl cause frequent urination

Click to see full answer Likewise, does Benadryl affect urination? Certain medications can cause urinary retention, especially in men with prostate enlargement. Antihistamines such as diphenhydramine (Benadryl, Compoz, Nytol, Sominex) and chlorpheniramine (Chlor-Trimeton, Allergy 8 Hr), as well as some older antidepressants, can relax the bladder too much and cause urination problems.